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KMID : 1188320110050040437
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Gut and Liver
2011 Volume.5 No. 4 p.437 ~ p.446
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Effect of Helicobacter pylori Eradication on the Development of Reflux Esophagitis and Gastroesophageal Reflux Symptoms: A Nationwide Multi-Center Prospective Study
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Kim Na-Young
Lee Sang-Woo
Kim Jin-Il
Baik Gwang-Ho
Kim Sung-Jung
Seo Geom-Seog
Oh Hyo-Jeong
Kim Sang-Wook
Jeong Hey-jin
Hong Su-Jin
Shim Ki-Nam
Shin Jeong-Eun
Park Seun-Ja
Im Eui-Hyeog
Park Jong-Jae
Cho Sung-Il
Jung Hyun-Chae
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Abstract
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Background/Aims:A two-year, prospective, nationwide multicenter study was undertaken to evaluate the effect of Helicobacter pylori eradication on the development of reflux esophagitis (RE) and gastroesophageal reflux disease (GERD) symptoms in the Korean population.
Methods:In total, 1,489 subjects without RE were enrolled at the outpatient clinics of 12 tertiary hospitals nationwide, and 452 subjects underwent follow-up (F/U) for 2 years to evaluate the development of RE and GERD symptoms.
Results:RE was found in 33 subjects (7.3% of 452 subjects) and 14 subjects (7.3% of 192 subjects) during the first and second year of F/U, respectively. H. pylori status was not associated with the development of RE. RE was found in six (9.0%) of 67 H. pylori-negative patients, in 26 (11.2%) of 233 eradicated subjects and in eight (7.0%) of 114 noneradicated subjects (p=0.532). Multivariate analysis showed that age ≥60 years (odds ratio [OR], 7.11; 95% confidence interval [CI], 1.92 to 26.41), alcohol consumption (OR, 4.43; 95% CI, 1.03 to 19.19) and F/U cholesterol levels ≥200 mg/dL (OR, 5.03; 95% CI, 1.32 to 19.17) were significant risk factors for the development of RE. There was no significant difference in the development of GERD symptoms or weight according to H. pylori status during the 2-year F/U.
Conclusions:Eradication of H. pylori did not affect the development of reflux esophagitis or GERD symptoms among patients in outpatient gastroenterology clinics in South Korea.
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KEYWORD
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Helicobacter pylori, Eradication, Reux esophagitis, Symptoms
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